Using optogenetics to control movement of a nematode

Using optogenetics to control movement of a nematode
The patterned-light illumination system and experimental results of the worm bending response upon laser beam excitation. Credit: Science Robotics (2021). DOI: 10.1126/scirobotics.abe3950

A team of researchers from the University of Toronto and Lunenfeld-Tanenbaum Research Institute, has developed a technique for controlling the movements of a live nematode using laser light. In their paper published in the journal Science Robotics, the group describes their technique. Adriana San-Miguel with North Carolina State University has published a Focus piece in the same journal issue outlining the work done by the team.

As scientists continue to create new kinds of robots, they often look to nature for inspiration. Researchers have found that studying locomotion in natural organisms is one of the best ways to develop strategies for developing microrobots. In this new effort, the researchers looked to the for inspiration. They note that prior efforts to control tiny robots have very often involved combining electronics with small creatures such as cockroaches, controlling them via , such as small charges of electricity. In this new effort, the researchers sought to gain better control of a creature using a different approach.

It involved genetically engineering several nematode specimens so that the muscles they used for locomotion would activate when exposed to light. They then injected a drug into the to paralyze them. Next, they placed them on an agar substrate beneath a triple-beam laser outfitted with a microscope and camera. Then, by optimally illuminating only small parts of the worm at a time, they found that they could force the nematode to move in desired directions without damaging it—the was of sufficient strength to penetrate the skin of the nematode and stimulate the muscles, which would constrict and relax on demand. The researchers demonstrated their control of the nematode by moving it through a small maze. They note that the key to properly directing their cyborg worm was to first study how the worm used muscles during locomotion and then to mimic those actions. They next plan to replicate their efforts using portable equipment to make their robotic worm usable in real-world applications.


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More information: Xianke Dong et al, Toward a living soft microrobot through optogenetic locomotion control of Caenorhabditis elegans, Science Robotics (2021). DOI: 10.1126/scirobotics.abe3950

Adriana San-Miguel, Optogenetics gets the worm, Science Robotics (2021). DOI: 10.1126/scirobotics.abj3937

Journal information: Science Robotics

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