An artificial neuron that can receive and release dopamine

An artificial neuron that can receive and release dopamine
Credit: Nature Electronics (2022). DOI: 10.1038/s41928-022-00803-0

A team of researchers from Nanjing University of Posts and Telecommunications and the Chinese Academy of Sciences in China and Nanyang Technological University and the Agency for Science Technology and Research in Singapore developed an artificial neuron that is able to communicate using the neurotransmitter dopamine. They published their creation and expected uses for it in the journal Nature Electronics.

As the researchers note, most machine-brain interfaces rely on as a communications medium, and those signals are generally one-way. Electrical signals generated by the brain are read and interpreted; signals are not sent to the brain. In this new effort, the researchers have taken a step toward making a that can communicate in both directions, and it is not based on electrical signals. Instead, it is chemically mediated.

The work involved building an artificial neuron that could both detect the presence of dopamine and also produce dopamine as a response mechanism. The neuron is made of graphene (a single sheet of carbon atoms) and a carbon nanotube electrode (a single sheet of carbon atoms rolled up into a tube). They then added a sensor capable of detecting the presence of dopamine and a device called a memristor that is capable of releasing dopamine using a heat-activated hydrogel, attached to another part of their artificial neuron.

Credit: Credit: Nature Electronics (2022). DOI: 10.1038/s41928-022-00803-0

The researchers tested the ability of their artificial neuron to communicate by placing it in a with some collected from a rat. They found it was able sense and respond to dopamine created and sent by the rat brain cells and also to produce some of its own, which then produced a response in the rat brain cells. They also found that they could activate a small mouse muscle sample by sending dopamine to a sciatic nerve, which was used to move a robot hand.

The researchers note that the memristor can be programmed to generate and send different amounts of dopamine depending on the application, just as brain cells do. They acknowledge that their setup is quite bulky, which would limit its use as a brain-machine interface, but note that it might be usable in its current form in a prosthetic device.


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More information: Ting Wang et al, A chemically mediated artificial neuron, Nature Electronics (2022). DOI: 10.1038/s41928-022-00803-0
Journal information: Nature Electronics

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